Related Experiment Video
Updated: May 24, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction
Duc Duy Vo1, Fabien Gautier, Philippe Juin
1Université de Rennes1, Laboratoire Sciences Chimiques de Rennes, CNRS UMR 6226, Avenue du Général Leclerc, 35042 Rennes Cedex, France.
Abstract:
This paper describes the synthesis of nine selected diaryl/heteroaryl-containing phenol and polyphenol derivatives which have been evaluated against Bax/Bcl-xL interaction in comparison with ABT-737. Using a BRET assay, six of these derivatives exhibit activity comparable to ABT-737 to disrupt Bax/Bcl-xL interaction. These preliminary results demonstrate that such polyphenol-derived molecules are attractive compounds regarding anticancer activity and that the phenol at position 3 is important regarding disruption of Bax/Bcl-xL interaction.
Related Concept Videos
The Intrinsic Apoptotic Pathway
Inhibition of Cdk Activity
Cellular Injury V: Apoptosis and Autophagy
