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Updated: May 24, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
[Long-term survival of ischemic stroke]
L Mérida-Rodrigo1, F Poveda-Gómez, M Camafort-Babkowski
1Servicio de Medicina Interna, Hospital Costa del Sol, Marbella, Málaga, España. LUISMERO@terra.es
Insights
Long-term survival after ischemic stroke is over 40%, with atherothrombotic stroke having a better prognosis than cardioembolic stroke. Key predictors of mortality include age and atrial fibrillation.
Area of Science:
- Neurology
- Vascular Medicine
- Epidemiology
Context:
- Ischemic stroke is a significant cause of long-term disability and mortality.
- The long-term prognosis of ischemic stroke, particularly differentiating between atherothrombotic and cardioembolic subtypes, requires further investigation.
Purpose:
- To investigate the long-term survival rates and identify predictors of mortality after a first-ever ischemic stroke.
- To compare the prognosis of atherothrombotic versus cardioembolic ischemic stroke over a 10-year period.
Summary:
- A retrospective cohort study followed 415 patients for 10 years post-first ischemic stroke.
- Overall 10-year survival was 55.4%, with atherothrombotic stroke (57.7%) showing better survival than cardioembolic stroke (43.7%).
- Predictors of mortality included age, renal failure, dyslipidemia, heart failure, atrial fibrillation, hemiplegia, acute ischemia signs, and edema; statin use and right middle cerebral artery territory involvement predicted better outcomes.
Impact:
- Provides crucial data on the long-term outcomes of ischemic stroke, informing clinical management and patient counseling.
- Highlights the differential prognosis between stroke subtypes, emphasizing the need for tailored treatment strategies.
- Identifies key modifiable and non-modifiable risk factors influencing long-term survival after ischemic stroke.
Objective:
Ischemic stroke is a serious vascular disease whose long term prognosis in all of its dimensions is not known. We have studied the long-term survival and its predictors after a first episode of acute ischemic stroke (atherothrombotic and cardioembolic).
Patients And Methods:
A retrospective cohort study was made of patients with a first episode of ischemic stroke. The ictus was classified into atherothrombotic, cardioembolic, lacunar and undetermined. Patients were followed up for 10 years.
Results:
A total of 415 cases (60% men) with mean age of 68.4 years, were included. Mean follow-up was 66 months (95% CI: 24-108 months). Overall survival at 10 years was 55.4% (54.9-55.9) (atherothrombotic, 57.7% vs cardioembolic, 43.7%, P=.002). In the multivariate analysis, variables related to mortality in acute ischemic stroke were age, chronic renal failure, dyslipidemia, history of heart failure, atrial fibrillation (AF), presenting as hemiplegia, signs of acute ischemia and perilesional edema in the brain scan on hospital admission. Involvement of the territory of right middle cerebral artery and treatment with statins were associated to a better prognosis.
Conclusions:
Survival of patients after ischemic stroke at ten year is over 40%, and atherothrombotic stroke as a better prognosis than cardioembolic one.
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