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Related Experiment Videos

Increased endothelin in experimental heart failure.

K B Margulies1, F L Hildebrand, A Lerman

  • 1Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn. 55905.

Circulation
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Circulating endothelin levels are significantly elevated in experimental congestive heart failure (CHF). Elevated endothelin is a sensitive indicator of CHF and may play a role in its pathophysiology.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Endothelin is a potent vasoconstrictor peptide found in normal plasma.
  • The role of endothelin in pathophysiological states is not well understood.

Purpose of the Study:

  • To investigate if circulating endothelin concentrations increase in experimental congestive heart failure (CHF).
  • To test the hypothesis that endothelin contributes to CHF pathophysiology.

Main Methods:

  • Induction of CHF in dogs via rapid ventricular pacing.
  • Measurement of plasma endothelin levels in dogs with CHF and control dogs.
  • Correlation analysis between endothelin levels and hemodynamic parameters (right atrial pressure, pulmonary capillary wedge pressure).

Main Results:

Related Experiment Videos

  • Plasma endothelin levels were significantly higher in dogs with CHF compared to controls (20.4 +/- 1.4 vs. 9.7 +/- 0.9 pg/ml, p < 0.0001).
  • Plasma endothelin > 14.0 pg/ml was a sensitive and specific indicator of significant CHF.
  • Endothelin levels correlated independently with right atrial pressure and pulmonary capillary wedge pressure in CHF dogs.

Conclusions:

  • Circulating endothelin is elevated in experimental congestive heart failure.
  • Increased endothelin may contribute to the pathophysiology of CHF.
  • Endothelin warrants further investigation as a therapeutic target in heart failure.