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Published on: August 16, 2018
Fragrance material review on 2,2,5-trimethyl-5-pentylcyclopentanone
J Scognamiglio1, L Jones, C S Letizia
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org
Abstract:
A toxicologic and dermatologic review of 2,2,5-trimethyl-5-pentylcyclopentanone when used as a fragrance ingredient is presented. 2,2,5-trimethyl-5-pentylcyclopentanone is a member of the fragrance structural group Ketones Cyclopentanones and Cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2,2,5-trimethyl-5-pentylcyclopentanone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, and phototoxicity data. A safety assessment of the entire Ketones Cyclopentanones and Cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Ketones Cyclopentanones and Cyclopentenones in fragrances.
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