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Ageing in Werner syndrome
M Goto1, S Iwaki-Egawa, Y Watanabe
1Division of Anti-ageing and Longevity Sciences, Department of Medical Technology, Toin University of Yokohama, Yokohama, Kanagawa, Japan. goto@cc.toin.ac.jp
Abstract:
Oxidative stress markers including pentosidine and homocysteine were examined comparing them with inflammation markers including highly sensitive C-reactive protein (hsCRP) and matrix metalloproteinase-9 (MMP-9) in serum from patients with Werner syndrome (WS) and healthy individuals. Elevation of serum pentosidine correlated significantly with normal aging in healthy individuals (p < 0.0004). Serum pentosidine in WS increased significantly compared with age-matched healthy individuals (p < 0.05). Serum homocysteine levels increased insignificantly with normal aging in healthy individuals and in WS compared with age-matched healthy individuals. As both pentosidine and homocysteine levels did not correlate with hsCRP or MMP-9, both oxidative stress markers may be differentially regulated by inflammation.
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