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Related Concept Videos

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Peptic Ulcer

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Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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Mooren's ulcer in children.

Anurag Mathur1, Jatin Ashar, Virender Sangwan

  • 1Cornea and Anterior Segment Services, LV Prasad Eye Institute, Hyderabad, India.

The British Journal of Ophthalmology
|March 20, 2012
PubMed
Summary
This summary is machine-generated.

Paediatric Mooren's peripheral ulcerative keratitis presents differently than in adults, with trauma being a common cause. Appropriate medical and surgical treatments can lead to good anatomical and visual outcomes in children.

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Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Corneal Diseases

Background:

  • Mooren's peripheral ulcerative keratitis (MPUK) is a rare, severe corneal disease.
  • Understanding its presentation and management in pediatric populations is crucial for effective treatment.

Purpose of the Study:

  • To delineate the epidemiology, clinical characteristics, management strategies, and outcomes of MPUK in children.
  • To compare pediatric MPUK features with those reported in adult populations.

Main Methods:

  • A retrospective case series of all patients under 18 years with MPUK treated at a single center from 1987 to 2010.
  • Data collected included demographics, clinical presentation, disease severity, treatments (medical and surgical), and outcomes (anatomical, functional, complications).

Main Results:

  • Eleven children (14 eyes) with MPUK were analyzed; trauma was the most frequent predisposing factor.
  • Pediatric MPUK exhibited more severe symptoms and corneal involvement compared to adults.
  • Combined medical (steroids, immunosuppressants) and surgical (tissue adhesive, AMT, keratoplasty, LSC-tx) interventions were employed, with most eyes achieving successful healing and stable vision.

Conclusions:

  • Pediatric MPUK demonstrates distinct demographic and clinical features compared to adult MPUK.
  • Effective anatomical and visual recovery is achievable with tailored medical and surgical interventions.
  • Judicious use of systemic steroids and immunosuppressants with close monitoring is recommended for pediatric MPUK management.