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Related Experiment Videos

Liver function tests in non-parenteral cocaine users.

J Tabasco-Minguillan1, D M Novick, M J Kreek

  • 1Department of Medicine, Beth Israel Medical Center, New York, NY 10003.

Drug and Alcohol Dependence
|October 1, 1990
PubMed
Summary
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Cocaine use rarely impacts liver function tests (LFT) in non-parenteral users. However, combining cocaine with alcohol may worsen cognitive and mood-related side effects.

Area of Science:

  • Hepatology
  • Clinical Toxicology
  • Neuroscience

Background:

  • Cocaine is a stimulant with potential systemic effects.
  • Liver function tests (LFTs) are standard biomarkers for liver health.
  • The impact of non-parenteral cocaine use on LFTs requires further investigation.

Purpose of the Study:

  • To assess the effect of cocaine on standard liver function tests (LFTs).
  • To compare LFTs in cocaine users with and without concurrent alcohol consumption.
  • To identify potential adverse effects associated with combined cocaine and alcohol use.

Main Methods:

  • Study included 46 individuals with no history of parenteral drug use or homosexuality.
  • Participants were divided into two groups: cocaine only (n=21) and cocaine with alcohol (n=25).

Related Experiment Videos

  • Standard liver function tests were performed and compared between groups.

    • Main Results:

    • Liver function tests were similar between the cocaine-only and cocaine-and-alcohol groups.
    • Only three patients exhibited elevated alanine aminotransferase levels, with two being hepatitis B carriers.
    • Patients consuming both cocaine and alcohol reported significantly more headaches, irritability, and memory loss.

    Conclusions:

    • Non-parenteral cocaine use is infrequently linked to significant abnormalities in liver function tests.
    • Concurrent alcohol consumption may amplify certain adverse effects of cocaine, particularly cognitive and mood-related symptoms.