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Related Experiment Video

Updated: May 24, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Exhaled nitric oxide and atherosclerosis.

Iiris Salonen¹, Kati Huttunen, Maija-Riitta Hirvonen

¹Laboratory of Clinical Chemistry, Kymenlaakso Hospital Services, Kotka, Finland. iiris.salonen@carea.fi

European Journal of Clinical Investigation

|March 21, 2012

Summary

Fractional exhaled nitric oxide (FENO) is lower in patients with ischemic heart disease, inversely correlating with triglycerides and HbA1c. This suggests FENO may reflect atherosclerosis risk markers.

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Area of Science:

Cardiology
Pulmonology
Biochemistry

Background:

Fractional exhaled nitric oxide (FENO) is used in asthma, pulmonary hypertension, and cystic fibrosis management.
Atherosclerosis involves nitric oxide (NO) inhibition and degradation.
The study investigated FENO's association with atherosclerosis risk markers.

Purpose of the Study:

To test the hypothesis that FENO is inversely associated with atherosclerosis risk markers.
To explore the relationship between FENO and diseases contributing to atherosclerosis progression.

Main Methods:

Compared long-term FENO values (24-week median) in 53 ischemic heart disease patients.
Correlated FENO with clinical and biochemical analyses.

Main Results:

FENO showed an inverse association with plasma triglycerides (P=0.01).
FENO was inversely associated with blood glycated hemoglobin A1c (P=0.03).
A trend for inverse association was observed with plasma glucose (P=0.10).

Conclusions:

FENO is inversely associated with triglycerides and HbA1c in stable ischemic heart disease patients.
This supports the hypothesis that FENO reflects atherosclerosis risk.
Endothelial dysfunction in hyperglycemia and high triglycerides may reduce NO production, lowering FENO.