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Updated: May 23, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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Published on: March 17, 2020

Granulocyte transfusions.

V Rimajova¹, L Sopko, J Martinka

¹Comenius University, Bratislava, Slovakia. veronika.rimajova@gmail.com

Bratislavske Lekarske Listy

|March 21, 2012

Summary

Severe neutropenia (low neutrophil count) increases infection risk. Granulocyte transfusions offer a potential life-saving option for patients with severe infections unresponsive to standard treatments.

Area of Science:

Hematology
Immunology
Infectious Diseases

Background:

Neutrophils are critical for combating bacterial and fungal infections.
Neutropenia significantly elevates the risk of life-threatening infections.
Despite advances in antimicrobials and growth factors, severe neutropenia remains a major cause of mortality in cancer patients and transplant recipients.

Purpose of the Study:

To review the renewed interest and clinical utility of granulocyte transfusions.
To evaluate granulocyte transfusions as a treatment for severe neutropenia with uncontrolled infections.

Main Methods:

Review of recent advances in apheresis technology and granulocyte mobilization techniques.
Consideration of clinical data supporting granulocyte transfusion efficacy.

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Main Results:

Advances in apheresis and granulocyte mobilization allow for the collection of large neutrophil quantities.
Granulocyte transfusions are a viable option for severe neutropenia and infection refractory to conventional therapy.

Conclusions:

Granulocyte transfusions represent a potentially life-saving intervention.
This treatment should be considered for patients with severe neutropenia and infections uncontrolled by standard antimicrobial and supportive care, weighing benefits against risks.