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Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
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Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Updated: May 23, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
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Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Therapeutic apheresis for renal disorders.

Amber P Sanchez1, David M Ward

  • 1Department of Medicine, Division of Nephrology, University of California, and Therapeutic Apheresis Program, UCSD Medical Center, San Diego, California 92103-8781, USA.

Seminars in Dialysis
|March 21, 2012
PubMed
Summary

Plasmapheresis effectively treats various nephrology conditions driven by autoantibodies and alloantibodies. However, its efficacy is limited for diseases involving smaller pathogenic molecules like FSGS.

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Last Updated: May 23, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Area of Science:

  • Nephrology
  • Immunology
  • Hematology

Background:

  • Apheresis modalities, including plasmapheresis, are crucial in managing specific nephrology indications.
  • Understanding the molecular biology and immunology of renal diseases is key to applying apheresis therapy effectively.
  • The review integrates current evidence with practical details for apheresis use in nephrology.

Purpose of the Study:

  • To summarize clinical evidence and practical aspects of plasmapheresis and other apheresis modalities in nephrology.
  • To discuss the molecular biology and immunology of renal diseases in the context of apheresis rationale.
  • To evaluate the role of apheresis alongside other treatments for various kidney diseases.

Main Methods:

  • Review of clinical evidence and practical details for plasmapheresis and apheresis in nephrology.
  • Discussion of molecular biology and immunology of relevant renal diseases.
  • Analysis of different plasmapheresis methods: standard, adsorption columns, and secondary filtration.

Main Results:

  • Plasmapheresis is effective for autoantibody-mediated diseases (anti-GBM GN, ANCA-related GN, TTP) and alloantibody-mediated diseases (transplant sensitization, humoral rejection).
  • Standard plasmapheresis and online plasma purification methods are discussed, with centrifugal plasmapheresis being the most studied.
  • Pathogenic molecules in FSGS and myeloma cast nephropathy are often too small for removal by current online purification methods.

Conclusions:

  • Plasmapheresis offers a viable treatment option for specific antibody-mediated kidney diseases.
  • Further research may be warranted for rare conditions like MPGN type 2 with specific abnormalities, despite limited case reports.
  • Photopheresis has not yet established a role in routine kidney transplant rejection management.