Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How much pressure causes a diabetic foot ulcer? An 18-month prospective study investigating plantar pressure characteristics in the lead up to ulceration.

Diabetes research and clinical practice·2026
Same author

Continuous glucose monitoring versus self-monitoring of blood glucose in individuals with type 2 diabetes: a randomised, multicentre, open-label, superiority trial.

The lancet. Diabetes & endocrinology·2026
Same author

Adaptation of the Transtibial Tunnel Technique for Limb Salvage Arterial Bypass with Anatomic Challenges.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

Artificial Intelligence in Diabetes Care.

Diabetes, obesity & metabolism·2026
Same author

Comparison of posterior slab cast with total contact cast in the management of diabetic foot ulcers: A randomized controlled trial.

Diabetes research and clinical practice·2026
Same author

Retrospective Cohort Study Analysing Response to Supervised Exercise Therapy and Subsequent Revascularization in Patients with Intermittent Claudication.

Journal of clinical medicine·2026
Same journal

Herbal Medicine and Metabolic Syndrome: Phytochemicals Targeting the Molecular Causes of Insulin Resistance and Related Comorbidities.

Current diabetes reviews·2026
Same journal

Low Glycemic Index Diets on Glycemic and Lipid Control Across Diverse Populations: A Systematic Review and Meta-Analysis.

Current diabetes reviews·2026
Same journal

From Dysbiosis to Diabetes: How Gut Microbiome Interventions Influence Type 2 Diabetes.

Current diabetes reviews·2026
Same journal

Innovative Phytochemical-Based Approaches for the Treatment of Diabetic Foot Ulcers.

Current diabetes reviews·2026
Same journal

Corrigendum to: Determination, Validation, and Development of Prediction Scores Related to Hypoglycemia Risk Factors Among Ambulatory Type 2 Diabetes Mellitus Patients in Bali, Indonesia.

Current diabetes reviews·2026
Same journal

Corrigendum to: The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarkers Scoping Review.

Current diabetes reviews·2026
See all related articles

Related Experiment Videos

The diabetic Charcot foot.

Sanjay U Dissanayake1, Frank L Bowling, Edward B Jude

  • 1Tameside Hospital NHS Foundation Trust, Fountain Street, Ashton-under-Lyne, OL6 9RW, Lancashire, UK.

Current Diabetes Reviews
|March 21, 2012
PubMed
Summary
This summary is machine-generated.

Charcot neuroarthropathy (CN) in diabetic patients is a severe foot condition. Bisphosphonate therapy shows promise in managing symptoms and reducing bone turnover markers.

Related Experiment Videos

Area of Science:

  • Diabetology
  • Orthopedics
  • Pharmacology

Background:

  • Charcot neuroarthropathy (CN) is a serious diabetic foot complication with incompletely understood pathophysiology.
  • Current treatment focuses on offloading and reducing weight-bearing.
  • Pharmacological targets include inhibiting osteoclast activation and pro-inflammatory cytokines.

Purpose of the Study:

  • To review the role of anti-resorption therapy, specifically bisphosphonates, in managing Charcot neuroarthropathy.
  • To evaluate the efficacy of bisphosphonates in improving clinical and biochemical markers of CN.

Main Methods:

  • Review of randomized trials investigating bisphosphonate use in Charcot neuroarthropathy.
  • Analysis of outcomes including symptom control, foot temperature, and bone turnover markers.

Main Results:

  • Bisphosphonate therapy demonstrated improved symptom control in patients with CN.
  • A more rapid decline in foot temperature was observed with bisphosphonate treatment.
  • Significant decreases in bone turnover markers were noted, indicating reduced bone resorption.

Conclusions:

  • Anti-resorption therapy with bisphosphonates is a viable option for managing Charcot neuroarthropathy.
  • Further understanding of molecular pathways could lead to novel adjunctive therapies for improved patient outcomes.