Two new triterpenoid saponins from the husks of Xanthoceras sorbifolia

Two new oleanane triterpenoid saponins, xanthohuskisides A (1) and B (2), were isolated from the husks of Xanthoceras sorbifolia. The structures of these two compounds were established as 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranosyl 16-deoxybarringtogenol C (1) and 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl 16-deoxybarringtogenol C (2), respectively, based on the analysis on their spectral data including NMR and HR-ESI-MS. The growth inhibitory activities of compounds 1 and 2 were assayed, and 2 showed moderate activity against U937 cell line with the IG(50) value of 82.85 ± 1.58 µM.