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Related Experiment Video

Updated: May 23, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Association between cardiac function and pulmonary function in hypertensive patients.

H Masugata¹, S Senda, H Okada

¹Department of Integrated Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Kagawa 761-0793, Japan. masugata@med.kagawa-u.ac.jp

The Journal of International Medical Research

|March 21, 2012

Summary

This summary is machine-generated.

Cardiac and pulmonary function are linked in hypertensive individuals. Reduced cardiac function, specifically lower left ventricular ejection fraction (LVEF), is associated with poorer lung function, indicating a need for preventive care.

Related Experiment Videos

Last Updated: May 23, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Area of Science:

Cardiology
Pulmonology
Hypertension Research

Background:

Hypertension is a major risk factor for cardiovascular and pulmonary diseases.
The relationship between cardiac and pulmonary function in hypertensive patients without overt cardiovascular disease is not fully understood.

Purpose of the Study:

To investigate the association between cardiac function parameters and pulmonary function metrics in hypertensive patients.
To identify specific cardiac dysfunction markers linked to reduced pulmonary function.

Main Methods:

43 hypertensive patients without overt cardiovascular disease underwent pulmonary function tests (percentage of predicted forced vital capacity [%FVC], 1-second forced expiratory volume to FVC ratio [FEV1/FVC]).
Cardiac function was assessed via echocardiography, measuring left ventricular ejection fraction (LVEF) and the E/e' ratio.
Multiple linear regression analysis was used to determine independent associations.

Main Results:

The E/e' ratio was independently associated with %FVC.
Left ventricular ejection fraction (LVEF) was independently associated with the FEV1/FVC ratio.
Hypertensive smokers (current or former) exhibited significantly lower LVEF and FEV1/FVC ratios compared to never smokers.

Conclusions:

Subclinical cardiac dysfunction is independently linked to reduced pulmonary function in hypertensive patients.
Hypertensive patients with diminished pulmonary function may require proactive interventions to mitigate heart failure progression.
Smoking status significantly impacts both cardiac and pulmonary function in this population.