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Updated: May 23, 2026

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
Published on: February 5, 2022
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
Alan D Goddard1, Anthony Watts
1Biomembrane Structure Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, UK.
Abstract:
Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
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