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Published on: June 7, 2016

Role of receptor for advanced glycation end products in cardiogenic shock

Simina-Ramona Selejan1, Janine Pöss, Lisa Hewera

  • 1Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

Critical Care Medicine
|March 21, 2012
PubMed
Abstract

Insights

Increased receptor for advanced glycation end products (RAGE) expression and decreased soluble RAGE in cardiogenic shock patients correlate with higher mortality. RAGE and soluble RAGE may serve as prognostic biomarkers and therapeutic targets.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Background:

  • Receptor for advanced glycation end products (RAGE) activation promotes inflammation and tissue injury.
  • Soluble RAGE may act as a decoy, neutralizing RAGE ligand-mediated damage.
  • The roles of RAGE and soluble RAGE in cardiogenic shock complicating myocardial infarction are not well-defined.

Purpose of the Study:

  • To investigate the association between RAGE expression, soluble RAGE levels, and mortality in patients with cardiogenic shock.
  • To evaluate RAGE and soluble RAGE as potential prognostic biomarkers in this patient population.

Main Methods:

  • Prospective observational cohort study involving 40 patients with cardiogenic shock, 20 with uncomplicated myocardial infarction, and 20 healthy controls.
  • Monocytic RAGE expression was measured by flow cytometry.
  • Plasma soluble RAGE levels were quantified using Western blotting.

Main Results:

  • Nonsurvivors of cardiogenic shock exhibited significantly higher monocytic RAGE expression (137.02±7.48 MFI) compared to survivors (67.80±8.33 MFI).
  • Nonsurvivors also showed significantly lower plasma soluble RAGE levels (79.87±10.62 AU) than survivors (127.65±10.52 AU).
  • RAGE expression and soluble RAGE levels were independent predictors of 28-day mortality in cardiogenic shock.

Conclusions:

  • Elevated RAGE expression and diminished soluble RAGE levels are implicated in the proinflammatory and destructive pathways contributing to mortality in cardiogenic shock.
  • RAGE and soluble RAGE show potential as prognostic biomarkers for survival in cardiogenic shock.
  • These molecules may represent novel therapeutic targets for managing cardiogenic shock.

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