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AQRNA-seq for Quantifying Small RNAs
Published on: February 2, 2024
sRNAbase: a Web resource for small RNAs in Enterobacteriaceae.
Sivasankaran Sathesh-Kumar1, Jayavel Sridhar, Ziauddin Ahamed Rafi
1Centre of Excellence in Bioinformatics, Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
In Silico Biology
|March 21, 2012
Summary
sRNAbase is a new database providing comprehensive information on bacterial small RNAs (sRNAs) in Enterobacteriaceae. It includes experimentally verified sRNAs and their genomic data to aid research.
Area of Science:
- Microbiology
- Bioinformatics
- Genomics
Background:
- Bacterial small RNAs (sRNAs) play crucial roles in bacterial survival and pathogenesis.
- Identification of bacterial sRNAs has largely relied on bio-computational methods.
- A centralized, curated resource for bacterial sRNAs is needed.
Purpose of the Study:
- To construct a manually curated web-resource, sRNAbase, for non-coding small RNAs in the Enterobacteriaceae family.
- To provide comprehensive and exhaustive information on experimentally verified bacterial sRNAs.
- To facilitate scientific research by consolidating sRNA data.
Main Methods:
- Manual curation of literature to identify experimentally verified bacterial small RNAs.
- Inclusion of partial/non-homologs from related genomes.
- Data compilation including genomic location, sequences, strand orientation, and associated gene information.
Main Results:
- sRNAbase contains information on 1986 entries from 80 sRNA families across 45 Enterobacteriaceae genomes.
- Entries include experimentally verified sRNAs and their genomic context.
- Data is linked to PubMed for further literature exploration.
Conclusions:
- sRNAbase serves as a valuable resource for researchers studying bacterial small RNAs in Enterobacteriaceae.
- The database facilitates access to curated information on sRNA function and location.
- It supports further investigation into the roles of sRNAs in bacterial biology.
