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Updated: May 23, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases
Sayna Norouzi1, Asghar Aghamohammadi, Setareh Mamishi
1Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Primary immunodeficiency diseases (PIDs) are a group of inherited disorders, characterized by defects of the immune system predisposing individuals to variety of manifestations, including recurrent infections and unusual vaccine complications. There are a number of PIDs prone to Bacillus Calmette-Guérin (BCG) complications. This review presents an update on our understanding about the BCGosis-susceptible PIDs, including severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial diseases.
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