[Cell-based strategies: novel perspectives for cancer therapy]

Related Experiment Video

Updated: May 23, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Valeria Simone1, Sabino Ciavarella, Stella D'Oronzo

  • 1Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione di Oncologia Medica, Università Aldo Moro, Bari.

Recenti Progressi in Medicina
|March 21, 2012
PubMed

Insights

Cellular therapies show promise in treating solid tumors. Genetically engineered adult stem cells are being developed to produce cancer-fighting molecules, advancing cell-based cancer treatment strategies.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cellular Therapy

Context:

  • Emerging field of oncology with growing evidence for cell-based immunotherapies.
  • Solid tumors present a significant challenge for existing cancer treatments.
  • Advancements in genetic engineering enable cell modification for therapeutic purposes.

Purpose:

  • To review preclinical and clinical findings on cell-based cancer treatment strategies.
  • To highlight the optimization of adult stem cells for cancer therapy.
  • To discuss the potential of genetically modified cells to produce cytotoxic molecules.

Summary:

  • Cellular therapies, particularly immunotherapies, are increasingly effective against solid tumors.
  • Adult stem cells are being genetically engineered to produce cancer-fighting cytotoxic molecules.
  • This review focuses on key preclinical and clinical results in cell-based cancer strategies.

Impact:

  • Provides a comprehensive overview of cell-based cancer treatment advancements.
  • Highlights the potential of genetically modified stem cells in oncology.
  • Informs future research and clinical applications of cellular therapies for solid tumors.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.