[Drug-induced liver injury]
Related Experiment Video
Updated: May 23, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Ludovico Abenavoli1, Emanuela Libri, Domenico Bosco
1Dipartmento di Scienze Della Salute, Università Magna Græcia, Catanzaro. l.abenavoli@unicz.it
Abstract:
Drug-induced liver injury represents the principal cause of acute liver failure and orthotopic liver transplantation in western country. A very large number of different drugs and medicinal herbs has been associated with liver injury but just for few of them we know the process that causes liver disease. All the people which ingest a large number of drugs present a risk of developing liver injury. Diagnosis is very difficult because a specific biomarker of damage is absent and the clinical picture is common to other liver diseases. A therapeutic approach is efficacy only in few cases. When a drug-induced liver injury is suspected, cessation of the drug is the first step in their management.
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