Related Experiment Video

Updated: May 23, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

[Expression and clinical significance of tumor-associated macrophages and microvessel density in ameloblastomas]

Mei-si Ren1, Jing Wang, Yan Guo

  • 1Department of Pathology, China Medical University, Shenyang, Liaoning Province, China. chinarenms@163.com

Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|March 21, 2012
PubMed
Abstract

Insights

Tumor-associated macrophages (TAMs) and microvessel density (MVD) are elevated in ameloblastomas (ABs), correlating with angiogenesis and potentially invasive growth.

Area of Science:

  • Oral pathology
  • Tumor microenvironment research
  • Cancer biology

Background:

  • Ameloblastomas (ABs) are odontogenic tumors with a high recurrence rate.
  • The tumor microenvironment, including immune cells and vascularization, influences tumor behavior.

Purpose of the Study:

  • To investigate the expression and clinical significance of tumor-associated macrophages (TAMs) and microvessel density (MVD) in ameloblastomas (ABs).

Main Methods:

  • Immunohistochemical analysis of TAMs (CD68) and MVD (CD34) in 101 ABs and 26 normal oral mucosa samples.
  • Quantification of TAMs and MVD, followed by statistical analysis (Student's t test, Pearson correlation).

Main Results:

  • TAMs and MVD were significantly higher in ABs compared to normal oral mucosa (P<0.05).
  • A positive correlation was observed between TAMs count and MVD count in ABs (r=0.428, P<0.05).

Conclusions:

  • Increased TAMs expression is associated with enhanced angiogenesis in ameloblastomas.
  • TAMs may play a crucial role in the invasive growth of ameloblastomas.

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...