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Related Concept Videos

Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 23, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Dynamic brain structural changes after left hemisphere subcortical stroke.

Fengmei Fan1, Chaozhe Zhu, Hai Chen

  • 1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People's Republic of China.

Human Brain Mapping
|March 21, 2012
PubMed
Summary
This summary is machine-generated.

Brain gray matter volume changes after subcortical stroke reveal distinct patterns. Cognitive-related brain area gray matter volume increases correlate with motor function recovery, suggesting a role in motor rehabilitation.

Keywords:
ischemic strokemotor cortexplasticitypost-stroke recoveryvolumetric MRI

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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

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Related Experiment Videos

Last Updated: May 23, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Subcortical stroke can lead to significant motor deficits.
  • Understanding dynamic structural brain changes post-stroke is crucial for identifying recovery mechanisms.

Purpose of the Study:

  • To quantify dynamic structural brain changes following subcortical stroke.
  • To identify brain regions contributing to motor recovery in affected limbs.

Main Methods:

  • Longitudinal high-resolution structural MRI in 10 subcortical stroke patients over one year.
  • Voxel-based morphometry (VBM) to calculate gray matter volume (GMV).
  • Mixed-effects modeling to analyze dynamic GMV changes and correlation with Motricity Index (MI) scores.

Main Results:

  • GMV decreased bilaterally in areas connected to lesions, suggesting secondary damage.
  • These decreased GMV areas did not correlate with motor recovery (MI scores).
  • GMV increased in motor and cognitive areas; only cognitive areas (hippocampus, precuneus) showed positive correlation with MI scores.

Conclusions:

  • Structural changes in brain areas connected to lesions may represent axonal degeneration, not directly impacting motor function recovery.
  • Structural reorganization in cognitive-related brain areas appears to facilitate motor function recovery after subcortical stroke.
  • Further research with larger sample sizes is needed to confirm these findings.