Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.8K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.0K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Tumor Progression02:07

Tumor Progression

7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single Cell Analysis of the Tumor Microenvironment Landscape Across the Disease Spectrum of Multiple Myeloma.

Blood·2026
Same author

Clinical outcomes and risk factors of cytomegalovirus reactivation in teclistamab-treated multiple myeloma patients.

Blood cancer journal·2026
Same author

Peripheral blood immune cell profiling and response to BCMA CAR-T cell therapy in relapsed refractory multiple myeloma.

Blood cancer journal·2026
Same author

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis.

Blood advances·2025
Same author

Equal survival for Black Americans with multiple myeloma when appropriately matched to White Americans.

Blood cancer journal·2025
Same author

The invisible divide: the impact of racial and geographic disparities on multiple myeloma outcomes - insights from a single-site study.

Haematologica·2025

Related Experiment Video

Updated: Jan 29, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K

Progress in myeloma stem cells.

Richard Dela Cruz1, Guido Tricot, Maurizio Zangari

  • 1Division of Hematology, Blood/Marrow Transplant and Myeloma Program 30 N 1900 E, 5C417, University of Utah, Salt Lake City, UT 84132, USA.

American Journal of Blood Research
|March 21, 2012
PubMed
Summary

Multiple myeloma stem cells drive drug resistance and relapse. Identifying their molecular characteristics and surface markers is crucial for developing targeted therapies to improve patient outcomes.

Keywords:
Cancer stem celland cell signalingdrug resistancemultiple myeloma

More Related Videos

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.5K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 24, 2007

14.0K

Related Experiment Videos

Last Updated: Jan 29, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.5K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 24, 2007

14.0K

Area of Science:

  • Hematologic Malignancies
  • Cancer Stem Cell Biology
  • Myeloma Research

Background:

  • Multiple myeloma (MM) is a prevalent hematologic malignancy with limited curative options.
  • MM drug resistance and relapse are significantly linked to the presence of MM stem cells.
  • Understanding MM stem cell biology is critical for advancing therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in identifying cancer stem cell surface markers.
  • To explore the molecular mechanisms underlying drug resistance and disease progression in multiple myeloma.
  • To highlight the importance of targeting MM stem cells for improved treatment efficacy.

Main Methods:

  • Review of existing literature on cancer stem cell markers.
  • Analysis of studies identifying specific cell populations in multiple myeloma.
  • Examination of molecular mechanisms related to therapeutic resistance.

Main Results:

  • Evidence suggests a minor MM cell fraction (CD138-, CD20+) possesses stem cell-like properties.
  • This fraction exhibits enhanced clonogenic potential and a memory B-cell phenotype (CD19+, CD27+).
  • Progress has been made in characterizing cell surface markers associated with MM stem cells.

Conclusions:

  • Targeting MM stem cells is a promising avenue for overcoming drug resistance.
  • Further research into MM stem cell surface markers and molecular pathways is essential.
  • Developing novel therapies focused on MM stem cells could significantly impact patient survival and disease management.