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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Published on: August 4, 2021

Stress and recurrent miscarriage.

M Craig1

  • 1Maudsley Hospital, Denmark Hill, London SES 8AE UK. m.craig@iop.kcl.ac.uk

Stress (Amsterdam, Netherlands)
|March 21, 2012
PubMed
Summary
This summary is machine-generated.

Stress significantly impacts unexplained recurrent miscarriages. Psychological support improved pregnancy outcomes, suggesting stress reduction is key. Further research explores stress

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Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
07:46

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Published on: October 13, 2023

Area of Science:

  • Reproductive Immunology
  • Psychoneuroimmunology

Background:

  • Unexplained recurrent miscarriage (URM) is a complex condition with unclear etiology.
  • Current research on stress in URM primarily focuses on psychological support interventions.
  • Conflicting results exist regarding personality traits and miscarriage rates.

Purpose of the Study:

  • To investigate the mechanisms by which stress may contribute to the etiology of unexplained recurrent miscarriage.
  • To explore the impact of psychological distress on immune parameters relevant to implantation.
  • To postulate an integrated model for stress-induced miscarriage.

Main Methods:

  • Review of existing research on psychological support and stress in URM.
  • Examination of animal studies detailing stress-induced alterations in immune parameters.
  • Analysis of immune cells involved in feto-maternal interactions and cytokine release.

Main Results:

  • Psychological support interventions show significantly higher successful pregnancy outcomes (84%) compared to no intervention (26%).
  • Animal studies indicate psychological distress elevates "abortive" tumor necrosis factor-alpha (TNF-a) and reduces "anti-abortive" transforming growth factor-beta2 (TGF-P2).
  • T cells, macrophages, and mast cells are implicated in TNF-a release at the feto-maternal interface.

Conclusions:

  • Stress is a likely contributor to the etiology of unexplained recurrent miscarriage.
  • Altered immune parameters, specifically cytokine profiles, represent a potential mechanism.
  • Further investigation into the interplay between stress, immune cells, and implantation is warranted.