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Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: May 23, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

The declining infrastructure of the aging brain.

David H Salat1

  • 1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA. salat@nmr.mgh.harvard.edu

Brain Connectivity
|March 22, 2012
PubMed
Summary

Aging degrades brain connectivity, impacting cognitive function. Understanding this decline in structural connectivity is key to restoring brain networks in older adults.

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • Brain function relies on interconnected neural hubs.
  • Myelinated nerve fibers facilitate inter-regional communication.
  • Aging can damage myelin and reduce nerve fibers, impairing brain communication.

Purpose of the Study:

  • To review studies on age-related decline in brain structural connectivity.
  • To explore consequences for functional network activity.
  • To discuss implications for ameliorating neural dysfunction in aging.

Main Methods:

  • Focus on neuroimaging methodologies for studying brain connectivity.
  • Review of research on age-associated changes in connective integrity.
  • Examination of neural and cognitive consequences of brain disconnection.

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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Related Experiment Videos

Last Updated: May 23, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Main Results:

  • Aging leads to deterioration in the brain's structural connectivity.
  • Reduced communication efficiency among neural regions is observed.
  • Cognitive function decline is linked to progressive disconnection.

Conclusions:

  • Age-associated decline in brain connectivity impacts cognitive function.
  • Understanding these changes is crucial for potential interventions.
  • Restoring brain infrastructure may improve function in older adults.