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Diets, phytochemicals, and chemoprevention of tumorigenesis

Chengguo Xing1, Thomas E Johnson, Paul J Limburg

  • 1Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. xingx009@umn.edu

Journal of Dietary Supplements
|March 22, 2012
PubMed

Insights

Dietary phytochemicals offer promising strategies for cancer chemoprevention. This review outlines methods for identifying and developing these natural compounds as potential cancer-fighting agents, with some currently in clinical trials.

Area of Science:

  • Oncology
  • Nutritional Science
  • Pharmacology

Background:

  • Cancer remains a leading cause of mortality and morbidity worldwide.
  • Chemoprevention is a crucial strategy to reduce cancer incidence and mortality.
  • Dietary components, particularly phytochemicals, are increasingly recognized for their potential chemopreventive properties.

Purpose of the Study:

  • To review the general approach for identifying and developing chemopreventive agents from dietary sources.
  • To highlight the role of phytochemicals in cancer chemoprevention.
  • To provide examples of promising candidates currently undergoing evaluation.

Main Methods:

  • Literature review of studies on dietary phytochemicals and cancer chemoprevention.
  • Analysis of methodologies used to identify and validate potential chemopreventive agents.
  • Case studies of selected phytochemicals with evidence of efficacy.

Main Results:

  • Diets and phytochemicals represent a rich resource for discovering cancer chemopreventive agents.
  • A systematic approach can identify promising candidates from natural sources.
  • Several dietary phytochemicals have demonstrated potential in preclinical and clinical settings.

Conclusions:

  • Dietary phytochemicals hold significant promise for cancer chemoprevention strategies.
  • Further research and clinical evaluation are warranted to translate these findings into effective cancer prevention therapies.
  • Integrating nutritional strategies into cancer prevention is a viable public health approach.

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