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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...

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Related Experiment Video

Updated: May 23, 2026

Preparation and Characterization of SDF-1&#945;-Chitosan-Dextran Sulfate Nanoparticles
12:00

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Dextran conjugates in drug delivery.

Jaleh Varshosaz1

  • 1Isfahan University of Medical Sciences, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Department of Pharmaceutics , Isfahan, Iran. varshosaz@pharm.mui.ac.ir

Expert Opinion on Drug Delivery
|March 22, 2012
PubMed
Summary
This summary is machine-generated.

Dextran conjugates are versatile polymeric carriers for enhanced drug delivery, particularly for anticancer agents. These systems improve drug efficacy and reduce side effects, paving the way for advanced therapeutics.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Dextran, a natural polysaccharide, is explored for novel drug delivery systems.
  • Its polymeric carriers enhance blood permanence and therapeutic effects, especially for antitumoral drugs.

Purpose of the Study:

  • To review the development and applications of dextran conjugates in drug delivery.
  • To highlight dextran's role in creating advanced pharmaceutical carriers.

Main Methods:

  • Review of literature on dextran conjugate development and applications.
  • Summary of dextran hydrogels, bioadhesive systems, and targeted delivery strategies.

Main Results:

  • Dextran conjugation enables tailor-made polymers for controlled drug release and targeting.
  • Dextran-antitumor drug conjugates significantly enhance chemotherapeutic agent effectiveness and cytotoxicity.

Conclusions:

  • Dextran conjugates offer significant potential for controlled drug release and targeted therapy, especially in oncology.
  • Future research should address clinical use barriers and safety of dextran as a drug carrier.