Related Experiment Video
Updated: May 23, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
Organ-specific responses to circulatory disturbances in heart failure: new insights
Edgar Argulian1, Craig McPherson, Marrick Kukin
1Division of Cardiology, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, New York, NY 10025, USA. eargulian@chpnet.org
Abstract:
Recent studies have provided new insights into the pathophysiology of congestive heart failure. Organ-specific responses to circulatory disturbances may differ via a hypoperfusion state and a venous congestion state. The liver and the kidneys serve as a good example of a differential injury pattern based on the predominant circulatory insult. Cardiorenal syndrome appears to be a kidney-specific response to predominantly right-sided backward heart failure ("congestive state"), rather than forward heart failure. Despite significant progress in our understanding of cardiorenal interactions, there is no specific therapy for the cardiorenal syndrome, which is a marker of the severity of the heart failure state.
Related Concept Videos
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Heart Failure VI: Adjunct Therapies
Heart Failure VII: Nursing Interventions
Heart Failure V: Medical Management
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System