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Updated: May 23, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
B effector cells in rheumatoid arthritis and experimental arthritis
Alison Finnegan1, Susan Ashaye, Keith M Hamel
1Department of Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Alison_Finnegan@rush.edu
Abstract:
Rheumatoid arthritis is a chronic autoimmune immune disease affecting approximately 1% of the population. There has been a renewed interest in the role of B cells in rheumatoid arthritis based on the evidence that B cell depletion therapy is effective in the treatment of disease. This review summarizes the current knowledge of the mechanisms by which B cells contribute to autoimmune arthritis including roles as autoantibody producing cells, antigen-presenting cells, cytokine producing cells, and regulatory cells.
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