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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

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Collateral Ganglia
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Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
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Peripheral neural targets in obesity.

Amanda J Page1, Erin Symonds, Madusha Peiris

  • 1Nerve-Gut Research Laboratory, Discipline of Medicine, South Australia, Australia.

British Journal of Pharmacology
|March 22, 2012
PubMed
Summary

New obesity treatments focus on gut mechanisms, not the brain, to increase satiety. Exploring gut-brain pathways offers promising, non-surgical avenues for appetite control and weight management.

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Last Updated: May 23, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
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04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Pharmacology

Background:

  • Obesity pharmacotherapy targeting the brain has faced challenges.
  • Treatments acting outside the brain, particularly in the gut, are under-researched.
  • The gut epithelium and vagal afferent system offer potential targets for satiety modulation.

Purpose of the Study:

  • To review mechano- and chemosensory pathways in the gut involved in appetite suppression.
  • To differentiate gastric and intestinal vagal afferent pathways.
  • To identify opportunities for non-surgical interventions targeting gut nutrient-sensing mechanisms.

Main Methods:

  • Review of existing literature on gut physiology and appetite regulation.
  • Analysis of mechano- and chemosensory pathways in the gastrointestinal tract.
  • Discussion of enteroendocrine factor activation of vagal afferent pathways.

Main Results:

  • Gut mechano- and chemosensory pathways play a crucial role in appetite suppression.
  • Gastric bypass surgery demonstrates the potential of manipulating gut nutrient loads for satiety.
  • Specific nutrient-sensing mechanisms throughout the GI tract are identified as potential therapeutic targets.

Conclusions:

  • Targeting gut-based satiety mechanisms offers a promising alternative to brain-centric obesity treatments.
  • Non-surgical approaches modulating gut-vagal signaling could lead to effective appetite control.
  • Further research into nutrient-sensing mechanisms in the GI tract is warranted for novel obesity therapies.