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Related Experiment Video

Updated: May 23, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

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Allergy in evolution.

Thomas A E Platts-Mills1

  • 1Asthma and Allergy Disease Center, University of Virginia, Charlottesville, Va., USA.

Chemical Immunology and Allergy
|March 22, 2012
PubMed
Summary
This summary is machine-generated.

Protein foreignness, determined by evolutionary distance, influences allergic responses to environmental and food allergens. Evolving allergic diseases, from minimal IgE to increased asthma, are linked to hygiene and lifestyle changes.

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Last Updated: May 23, 2026

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Area of Science:

  • Immunology
  • Evolutionary Biology
  • Environmental Health

Background:

  • Allergic diseases are influenced by the evolutionary relatedness of proteins encountered in the environment.
  • Understanding allergen sources like mammals (cats) versus arthropods (mites, cockroaches) is crucial.
  • Allergic disease progression involves shifts in immunoglobulin E (IgE) production and asthma prevalence.

Observation:

  • The perceived 'foreignness' of proteins is a key factor in immune responses.
  • Evolutionary distance from humans dictates the allergenic potential of various proteins.
  • Changes in hygiene and lifestyle correlate with the rise of allergic conditions.

Findings:

  • Mammalian and arthropod allergens elicit different immune responses due to evolutionary divergence.
  • Food allergens also vary in their allergenic impact based on protein origin.
  • The evolution of allergic disease includes a transition from low IgE states to high IgE and increased asthma.

Implications:

  • This research provides a framework for understanding diverse allergenicity.
  • It highlights the need to consider evolutionary factors in allergy research and treatment.
  • Further investigation into hygiene and lifestyle impacts is essential for managing the increasing burden of allergic diseases.