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Bone mineral density in patients with atopic dermatitis
Chemical Immunology and Allergy
|March 22, 2012
Summary
One third of patients with moderate-to-severe atopic dermatitis (AD) have low bone mineral density (BMD), primarily males. This low BMD did not progress rapidly over two years, but long-term studies are recommended.
Area of Science:
- Dermatology
- Endocrinology
- Bone Metabolism
Background:
- Moderate-to-severe atopic dermatitis (AD) affects bone health.
- Prevalence of low bone mineral density (BMD) in AD patients is not well-established.
Purpose of the Study:
- To investigate the prevalence of low BMD in patients with moderate-to-severe AD.
- To assess the progression of low BMD over a 2-year period.
- To evaluate potential contributing factors and treatment implications for low BMD in AD.
Main Methods:
- Cross-sectional study of BMD in moderate-to-severe AD patients.
- 2-year follow-up to assess BMD changes.
- Analysis of potential factors like topical corticosteroid use and chronic inflammation.
Main Results:
- One third of AD patients exhibited low BMD, predominantly males.
- Low BMD at baseline showed slow progression over 2 years.
- Neither topical corticosteroids nor chronic inflammation were definitively linked to low BMD.
Conclusions:
- Low BMD is a significant finding in moderate-to-severe AD patients.
- The progression of low BMD in this cohort is slow.
- Further long-term studies are needed to understand BMD changes from AD onset and guide treatment.
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