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Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum
Yong-Xia Tan1, Hong-Qing Wang, Ruo-Yun Chen
1Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China.
Abstract:
Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1-3) were obtained during our ongoing investigation of an ethanol extract from the stem bark of Morus wittiorum. Their structures were elucidated on the basis of spectroscopic data. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC(50) value of 1.45μM.