Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues
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Updated: May 23, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Scott P Nichols1, Wesley L Storm, Ahyeon Koh
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. snichols@unc.edu
Abstract:
Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair.
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