Related Experiment Video
Updated: May 23, 2026

Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
[Evaluation of antiepileptic effects of cortexin in a model of convulsions]
Abstract:
We studied antiepileptic effects of cortexin administered in doses 0,015, 0,15 and 1,0 mg/kg intraperitoneally in solution or intranasally in the complex with nanoparticles in a model of acute and chronic convulsions in rats induced by pentylenetetrazole. In the model of epileptic status, the long-term preliminary administration of cortexin had no effect on convulsions while in the model of chronic convulsions (temporal epilepsy), cortexin had a marked dose-dependent antiepileptic effect. The influence of cortexin on neuroplasticity and its clinical potential are discussed.
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