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Updated: May 23, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Imaging hypoxia in gliomas.

I Mendichovszky¹, A Jackson

¹Wolfson Molecular Imaging Centre, University of Manchester, Withington, Manchester, UK.

The British Journal of Radiology

|March 22, 2012

Summary

This summary is machine-generated.

This review explores imaging techniques for measuring tumor hypoxia in gliomas. Advances in medical imaging offer new ways to visualize and understand hypoxia

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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

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In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model

In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model

Published on: October 3, 2011

Area of Science:

Oncology
Radiology
Neuroscience

Background:

Hypoxia is crucial in glioma development, angiogenesis, growth, and treatment resistance.
Accurate measurement of tumor hypoxia is essential for effective glioma management.

Purpose of the Study:

To review current imaging approaches for measuring hypoxia in human gliomas.
To provide insights into recent advances and future directions in glioma hypoxia imaging.

Main Methods:

Review of literature on invasive and non-invasive hypoxia detection methods.
Discussion of positron emission tomography (PET) tracers (e.g., (18)F-MISO, FRP-170, Cu-ATSM, (99m)Tc- and (68)Ga-MN).
Overview of advanced magnetic resonance imaging (MRI) techniques (e.g., BOLD MRI, oxygen-enhanced MRI, DWI-MRI, DCE-MRI, (1)H-MRS).

Main Results:

Various imaging modalities exist for assessing glioma hypoxia.
PET and advanced MRI techniques show promise for in vitro and in vivo hypoxia imaging.
Eppendorf polarographic O(2) microelectrodes offer invasive monitoring.

Conclusions:

Significant advances in medical imaging facilitate hypoxia assessment in gliomas.
Continued development in imaging technologies is vital for improving glioma diagnosis and treatment.