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Clinical applications of imaging biomarkers. Part 2. The neurosurgeon's perspective
1The Walton Centre NHS Foundation Trust, University of Liverpool, Liverpool, UK. abrodbelt@doctors.org.uk
Abstract:
Advances in imaging, including multivoxel spectroscopy, tractography, functional MRI and positron emission spectroscopy, are being used by neurosurgeons to target aggressive areas in gliomas, and to help identify tumour boundaries, functional areas and tracts. Neuro-oncological surgeons need to understand these techniques to help maximise tumour resection, while minimising morbidity in an attempt to improve the quality of patient outcome. This article reviews the evidence for the practical use of multimodal imaging in modern glioma surgery.
Insights
Multimodal imaging techniques like functional MRI help neurosurgeons precisely target aggressive gliomas. Understanding these advanced imaging methods improves tumor resection and patient outcomes in neuro-oncology.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Medical Imaging
Background:
- Gliomas present challenges in surgical resection due to their infiltrative nature and proximity to critical brain structures.
- Maximizing tumor removal while preserving neurological function is paramount for improving patient prognosis.
Purpose of the Study:
- To review the evidence supporting the practical application of multimodal imaging in contemporary glioma surgery.
- To highlight how advanced imaging techniques aid neurosurgeons in targeting aggressive tumor areas and defining resection margins.
Main Methods:
- Review of current literature on advanced neuroimaging techniques.
- Discussion of multivoxel spectroscopy, tractography, functional MRI, and positron emission spectroscopy in glioma management.
Main Results:
- Multimodal imaging provides critical information for surgical planning and execution in glioma cases.
- These techniques assist in identifying tumor boundaries, eloquent functional areas, and critical white matter tracts.
Conclusions:
- Neurosurgeons must integrate multimodal imaging into their practice to optimize glioma resection.
- Effective use of these technologies can lead to improved patient outcomes and reduced surgical morbidity.
