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Updated: May 23, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Autoimmunity and Graves' disease
1Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, Minnesota, USA. bahn.rebecca@mayo.edu
Abstract:
Current treatment options for Graves' hyperthyroidism and the related ophthalmopathy (GO) are not uniformly effective and carry with them potentially serious side effects. As a result, efforts have been focused on the development of novel therapies. Progress has been made, particularly in the production of thyroid-stimulating hormone receptor (TSHR) antagonists, as either monoclonal blocking antibodies or small-molecule ligands. In addition, rituximab (RTX) is the first targeted biological therapy to be studied as treatment for these conditions.
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