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Updated: May 23, 2026

RiboTag Immunoprecipitation in the Germ Cells of the Male Mouse
Published on: March 4, 2020
Understanding the sexome: measuring and reporting sex differences in gene systems
Arthur P Arnold1, Aldons J Lusis
1Department of Integrative Biology and Physiology, University of California, Los Angeles, California 90095-7239, USA. arnold@ucla.edu
Abstract:
The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome," which is the sum of sex-biased effects on gene networks and cell systems. The global search for sites and mechanisms of sex-specific regulation in diverse tissues will provide unanticipated insights into physiological regulation and targets for novel therapies.
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