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Published on: October 19, 2014
An exploratory epidemiological study of Langerhans cell histiocytosis
Rajkumar Venkatramani1, Shira Rosenberg, Gitanjali Indramohan
1Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Abstract:
We explored potential risk factors associated with Langerhans cell histiocytosis (LCH) in a predominantly Hispanic population in Los Angeles. Sixty children with LCH (cases) and, 150 randomly selected patients (controls) were interviewed. There was no statistically significant difference between cases and controls in the following: Family history of thyroid disease, smokers in the family, maternal problems during pregnancy, and pesticide exposure. Cases were more likely to report a family history of cancer (OR 2.5), infection during infancy (OR 2.76), and parental occupational exposure to metal, granites, or wood dust (OR 2.48).
