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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
Published on: February 27, 2011
The mouse-human anatomy ontology mapping project
Terry F Hayamizu1, Sherri de Coronado, Gilberto Fragoso
1The Jackson Laboratory, Bar Harbor, ME 04609, USA. terry.hayamizu@jax.org
Database : the Journal of Biological Databases and Curation
|March 22, 2012
Summary
The Mouse-Human Anatomy Project (MHAP) mapped anatomical terms between mouse and human models, creating essential links for biological data integration. This harmonization effort supports comparative research across species.
Area of Science:
- Bioinformatics
- Comparative Anatomy
- Ontology Engineering
Background:
- Standardizing anatomical terminology across species is crucial for integrating biological data.
- Existing resources like the Adult Mouse Anatomy (MA) ontology and NCI Thesaurus (NCIt) require harmonization for comparative studies.
Purpose of the Study:
- To map and harmonize anatomical terms between mouse and human models.
- To facilitate data linking and comparative analysis between mouse and human research.
- To provide a curated set of mappings for broader scientific resource utilization.
Main Methods:
- Comparative analysis of the MA ontology and NCIt using identified software tools.
- Determination and validation of matches between mouse and human anatomy terms.
- Iterative refinement and updating of mapping files as ontologies evolve.
Main Results:
- A curated set of validated mappings between mouse and human anatomy ontologies was generated.
- The developed mappings enable the linking of biological data across species.
- The project provides insights into ontology comparison and mapping methodologies.
Conclusions:
- The Mouse-Human Anatomy Project successfully harmonized anatomical terms, enhancing cross-species data integration.
- The generated mappings serve as a valuable resource for comparative biology and translational research.
- Further development and applications of these ontologies and mappings are anticipated.
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