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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 23, 2026

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
05:42

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Second primary oral melanoma: A rare presentation.

Meghanand T Nayak1, Anjali Singh, Rm Mathur

  • 1Department of Oral and Maxillofacial Pathology, Saraswati Dental College and Hospital, Lucknow, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|March 22, 2012
PubMed
Summary

This case report details a rare second primary oral melanoma in a 55-year-old female. Early diagnosis and prompt treatment are crucial for improving outcomes in melanoma patients.

Keywords:
Buccal mucosaHMB-45follow-uphard palateoral melanomasecond primary malignancies

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Melanomas are aggressive neoplasms of melanocytic origin with unpredictable behavior.
  • Oral melanomas are rare, aggressive, and associated with a poor prognosis.
  • Patients with a history of melanoma have an increased risk of developing a second primary tumor.

Observation:

  • A case of a second primary oral melanoma in a 55-year-old female is presented.
  • The patient had a prior history of melanoma, increasing her risk.
  • The presentation of the primary and secondary lesions was anachronistic, making the case clinically interesting.

Findings:

  • Immunohistochemical analysis revealed HMB-45 positivity and S-100 negativity.
  • These findings are characteristic of melanocytic origin.

Implications:

  • This case highlights the importance of vigilance for second primary melanomas, especially in patients with a prior diagnosis.
  • Prompt diagnosis and treatment are critical for managing oral melanoma and improving patient survival.
  • Understanding immunohistochemical markers aids in accurate diagnosis and classification of melanomas.