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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Related Experiment Video

Updated: May 23, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Do dietary supplements help promote weight loss?

Stacey J Bell1, Wendy Van Ausdal, Greg Grochoski

  • 1IdeaSphere Inc, Belmont, MA 02478, USA. staceyjbell@yahoo.com

Journal of Dietary Supplements
|March 23, 2012
PubMed
Summary

Effective weight loss supplements are crucial for the overweight population. This review identifies specific dietary ingredients and blends that promote safe and effective weight loss, some surpassing over-the-counter options.

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Last Updated: May 23, 2026

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Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet
13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

Area of Science:

  • Nutrition Science
  • Dietary Supplements
  • Weight Management

Background:

  • Two-thirds of the US population is overweight or obese, necessitating new weight loss strategies.
  • Dietary supplements are a popular weight loss option, but clinical evidence for efficacy is often lacking.
  • Identifying effective supplements is crucial for public health.

Purpose of the Study:

  • To identify and evaluate published clinical studies on the effectiveness of dietary supplements for weight loss.
  • To determine which specific ingredients and blends demonstrate efficacy in promoting weight loss.
  • To compare the effectiveness of identified supplements against over-the-counter (OTC) orlistat.

Main Methods:

  • Systematic literature search for published clinical studies on dietary supplements for weight loss.
  • Defined effectiveness as promoting 1-2 lbs of weight loss per week.
  • Compared weight loss results of supplements to OTC orlistat.

Main Results:

  • Only 14 published studies were identified among numerous marketed supplements.
  • Four individual ingredients and three blends were found to be effective for weight loss.
  • Five single ingredients and three blends showed greater weight loss than OTC orlistat.

Conclusions:

  • A limited number of dietary supplements have demonstrated clinical efficacy for weight loss.
  • Healthcare providers and consumers should prioritize supplements with proven effectiveness.
  • Further research may be needed to expand the options for evidence-based weight management supplements.