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Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study.

Eujin Cho¹, Sang Hyun Cho, Jeong Deuk Lee

¹Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

International Journal of Dermatology

|March 23, 2012

Summary

This summary is machine-generated.

Progressive cribriform and zosteriform hyperpigmentation (PCZH) presents with increased melanin in lesions along Blaschko lines. Histopathology reveals higher melanin content but not increased melanocytes, with no sex-based differences.

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Area of Science:

Dermatology
Pigmentary Disorders
Histopathology

Background:

Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a rare pigmentation disorder.
Limited clinicopathologic data exists in English literature.

Purpose of the Study:

To define the clinical and histologic features of PCZH.
To provide the first clinicopathologic study of PCZH.

Main Methods:

Retrospective review of 30 PCZH patients diagnosed between 1999-2009.
Analysis of medical records, clinical photographs, and histopathologic findings.

Main Results:

Mean age at onset was 14.27 years; trunk was the most common site.
Histology showed increased basal layer melanin, pigmentary incontinence in 13/30 cases, but no difference in melanocyte count.
Lesions followed Blaschko lines, with localized rather than diffuse patterns.

Conclusions:

PCZH shows no significant difference in prevalence or onset between sexes.
Histopathologic findings are characterized by increased melanin content, not melanocyte number.
Lesions are localized along Blaschko lines.