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Related Experiment Video

Updated: May 23, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Calcium signalling remodelling and disease.

Michael J Berridge¹

¹Babraham Institute, Babraham, Cambridge CB22 3AT, U.K. michael.berridge@babraham.ac.uk

Biochemical Society Transactions

|March 23, 2012

Summary

This summary is machine-generated.

Calcium (Ca2+) signaling is vital for cell function. Dysregulation of these signals, particularly through inositol 1,4,5-trisphosphate (InsP3) pathways, is linked to major human diseases like Alzheimer's and cardiac conditions.

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Last Updated: May 23, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

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Published on: February 18, 2020

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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

Area of Science:

Cellular biology
Neuroscience
Biochemistry

Background:

Calcium (Ca2+) signaling pathways are crucial for diverse cellular functions.
Inositol 1,4,5-trisphosphate (InsP3)-mediated Ca2+ release is a key component of many signaling systems.
Transcriptional regulation maintains the stability of cell-specific Ca2+ signaling.

Purpose of the Study:

To explore the plasticity and dysregulation of Ca2+ signaling systems.
To investigate the link between altered Ca2+ signaling and human diseases.

Main Methods:

Analysis of Ca2+ signaling dynamics.
Investigation of transcriptional control mechanisms.
Review of disease-associated signaling alterations.

Main Results:

Ca2+ signaling systems exhibit phenotypic plasticity, allowing for remodeling.
Dysregulation, characterized by excessively high or low Ca2+ signals, can occur.
Subtle alterations in Ca2+ signaling are associated with major diseases, including cardiac disease, schizophrenia, bipolar disorder, and Alzheimer's disease.

Conclusions:

Cellular Ca2+ signaling is dynamic and susceptible to homeostatic imbalances.
Aberrant Ca2+ signaling represents a significant factor in the pathophysiology of various complex human diseases.
Understanding these signaling dysregulations may offer therapeutic targets for neurological and cardiac conditions.