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Related Experiment Video

Updated: May 23, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Leukotriene D4 bronchial provocation test: methodology and diagnostic value.

Weijie Guan1, Jinping Zheng, Yi Gao

  • 1State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.

Current Medical Research and Opinion
|March 23, 2012
PubMed
Summary

The leukotriene D4 (LTD4) bronchial provocation test effectively diagnoses asthma by measuring airway responsiveness. This test is safe and well-tolerated in patients, with symptoms resolving quickly after treatment.

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Last Updated: May 23, 2026

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Published on: July 10, 2018

Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology
  • Respiratory Physiology

Background:

  • Leukotriene D4 (LTD4) is a known bronchoconstrictor, but its role in asthma with varying inflammation phenotypes is not fully understood.
  • Airway hyperresponsiveness is a hallmark of asthma, yet specific responses to LTD4 require further investigation.

Purpose of the Study:

  • To establish a reliable methodology for the LTD4 bronchial provocation test.
  • To investigate airway responsiveness to LTD4 in asthmatics and normal controls.
  • To assess the diagnostic value and safety of the LTD4 bronchial provocation test.

Main Methods:

  • Conducted LTD4 bronchial provocation tests on 62 asthmatics and 21 healthy individuals.
  • Assessed airway responsiveness using the cumulative dosage causing a 20% fall in FEV1 (PD(20)FEV1-LTD4).
  • Utilized receiver operating characteristic (ROC) curves for diagnostic value assessment and recorded all adverse events.

Main Results:

  • Asthmatics exhibited significantly higher airway responsiveness to LTD4 compared to controls (0.410 nmol vs. 5.00 nmol).
  • The ROC curve demonstrated high diagnostic accuracy (AUC: 0.914).
  • Common adverse events like dyspnea and chest tightness were transient and resolved within 15 minutes with salbutamol, with no serious events reported.

Conclusions:

  • The developed LTD4 bronchial provocation test is an effective and well-tolerated diagnostic tool for asthma.
  • The test shows high diagnostic value and safety, supporting its potential clinical application.
  • Further research is recommended to gather more evidence on the long-term safety and efficacy of the LTD4 test.