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Updated: May 23, 2026
06:23
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Spondylodiscitis: standards of current treatment
Alberto Di Martino1, Nicola Papapietro, Angela Lanotte
1Center for Integrated Research, Department of Orthopaedics and Trauma Surgery, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200 Rome 00128, Italy. a.dimartino@unicampus.it
Current Medical Research and Opinion
|March 23, 2012
Summary
Conservative therapy, including targeted antibiotics and bracing, is the primary treatment for spondylodiscitis (SD). Surgery is reserved for complications like deformity or neurological compromise, with evolving diagnostic and therapeutic strategies.
Area of Science:
- Orthopedics
- Infectious Diseases
- Neurosurgery
Background:
- Spinal infections (spondylodiscitis, SD) pose significant clinical challenges, often necessitating aggressive medical or surgical intervention.
- Risk factors include advanced age, diabetes, immunosuppression, and prior spinal procedures.
- Lumbar spine involvement is most common, with thoracic lesions posing a higher risk of neurological deficits.
Purpose of the Study:
- To outline evidence-based therapeutic standards for spondylodiscitis (SD).
- To emphasize pharmacological management, bracing, and surgical indications.
- To review current diagnostic and treatment approaches.
Main Methods:
- Comprehensive literature search of PubMed and Google Scholar.
- Keywords included spondylodiscitis, spine infection, therapy, surgery, radiology, and treatment.
- Review of relevant publications and reference citations for established and emerging standards.
Main Results:
- Conservative management with targeted antibiotic therapy and bracing is the current standard of care for SD.
- Accurate diagnosis and individualized treatment enhance outcomes and reduce failure rates.
- Surgical intervention is indicated for complications such as deformity, neural compression, or neurological compromise.
Conclusions:
- Evolving diagnostic tools and novel therapeutic strategies, including growth factors and cell therapy, are advancing SD management.
- Optimized conservative treatment improves clinical results and minimizes the need for surgery.
- Future research directions include enhancing infection eradication and bone healing post-operatively.
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