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Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded
Georgios I Tagarakis1, Christos Voucharas, Fani Tsolaki
1Department of Cardiovascular and Thoracic Surgery, University Hospital of Larissa, Thessaly, Greece. gtagarakis@gmail.com
Background:
To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.
Methods:
We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).
Results:
Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-CONCLUSIONS: Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future.
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