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Protocol for Isolating the Mouse Circle of Willis
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Published on: October 22, 2016

[Willis and his circle].

Jan van Gijn1, Joost P Gijselhart

  • 1Nederlands Tijdschrift voor Geneeskunde, Amsterdam, the Netherlands. jan@vangijn.com

Nederlands Tijdschrift Voor Geneeskunde
|March 23, 2012
PubMed
Summary
This summary is machine-generated.

Thomas Willis detailed the brain's arterial circle, a crucial vascular structure. His work significantly advanced the understanding of cerebral circulation and neuroanatomy.

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Area of Science:

  • Neuroscience
  • Medical History
  • Vascular Anatomy

Background:

  • Thomas Willis (1621-1675) was a prominent physician and anatomist during a period of significant scientific inquiry and political upheaval in England.
  • He participated in early scientific societies, conducting experiments and animal studies alongside contemporaries like Christopher Wren and Robert Hooke.
  • Willis's medical practice and academic pursuits intensified after the 1660 Restoration, leading to his focused research on the brain.

Discussion:

  • Willis's seminal work, 'Cerebri anatome' (1664), provided detailed anatomical descriptions of the brain.
  • Illustrated by Christopher Wren, the publication highlighted the arterial circle at the base of the brain.
  • This arterial circle, also known as the Circle of Willis, was crucial for understanding cerebral blood flow and its physiological significance.

Key Insights:

  • The 'Cerebri anatome' offered a comprehensive description of the brain's structure, moving beyond previous incomplete accounts.
  • Willis elucidated the physiological advantages of the arterial circle in ensuring continuous blood supply to the brain.
  • His work built upon, yet significantly surpassed, prior written descriptions by scholars like Wepfer.

Outlook:

  • Thomas Willis's anatomical descriptions laid foundational knowledge for modern neurology and cerebrovascular studies.
  • The detailed study of the Circle of Willis continues to be relevant in clinical neurology, neurosurgery, and stroke research.
  • His legacy underscores the importance of meticulous anatomical investigation in advancing medical understanding.