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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Related Experiment Video

Updated: May 23, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Good and bad fever.

Jean-Marc Cavaillon1

  • 1Unit of Cytokines & Inflammation, Department of Infection and Epidemiology, Institut Pasteur, 28 rue Dr Roux, F-75015 Paris, France. jean-marc.cavaillon@pasteur.fr

Critical Care (London, England)
|March 23, 2012
PubMed
Summary
This summary is machine-generated.

Antipyretic drugs may worsen outcomes for sepsis patients, despite fever being part of the immune response. High body temperature in non-infectious intensive care patients is also linked to increased mortality.

More Related Videos

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Area of Science:

  • Immunology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Fever is a critical component of the innate immune response to infection.
  • The role of fever and its management in critical illness remains complex.
  • Antipyretic medications are commonly used to reduce fever.

Purpose of the Study:

  • To investigate the association between antipyretic drug use and patient outcomes in sepsis.
  • To examine the relationship between high body temperature and mortality in non-infectious intensive care unit (ICU) patients.

Main Methods:

  • Observational study analyzing patient data.
  • Comparison of outcomes between patients receiving antipyretics and those who did not.
  • Correlation analysis of body temperature and mortality in different patient cohorts.

Main Results:

  • A significant association was found between the use of antipyretic drugs and poorer outcomes in patients with sepsis.
  • Elevated body temperature in non-infectious ICU patients was correlated with higher mortality rates.

Conclusions:

  • The findings suggest that antipyretic use might negatively impact sepsis outcomes.
  • Maintaining high body temperature in non-infectious critically ill patients is associated with increased mortality risk.