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Updated: May 5, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
Published on: March 14, 2013
Innovation: Metabolomics: the apogee of the omics trilogy
Gary J Patti1, Oscar Yanes, Gary Siuzdak
1Department of Chemistry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. gjpattij@wustl.edu
Abstract:
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping our understanding of cell biology, physiology and medicine.
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